Therapeutic Experience

Cardiology

Thorough QT (TQT)

Cardiovascular

Atherosclerosis

Chronic heart failure

Dyslipidemia; mixed dyslipidemia

Hypercholesterolemia; homozygous familial hypercholesterolemia

Hyperlipidemia

Hypertension

Hypertriglyceridemia

Low-molecular weight heparin; antithrombotic

Thrombocytopenia

Dermatology

Acne vulgaris

Acute bacterial skin and skin structure infections

Antifungals

Atopic dermatitis

Complicated and uncomplicated skin and skin structure infection

Invasive fungal disease/infection

Psoriasis

Skin and soft tissue infections

Urticaria

Endocrinology

Cushing syndrome

Deficiency or lack of norepinephrine

Excess central corticotropin-releasing factor

Human growth hormone; growth failure

Hypogonadism (testosterone deficiency)

Primary and secondary adrenocortical insufficiency; adrenocortical reserve

Thyroidism

Type 2 diabetes mellitus (T2DM)

Gastroenterology

Diabetic gastroparesis

Diarrhea-predominant irritable bowel syndrome (IBS)

Gastroesophageal reflux disease (GERD)

Genetic Diseases

Gaucher's disease type 1

Hepatology

Primary biliary cirrhosis

Infectious Diseases

Broad-spectrum fluoroquinolone

Community-acquired bacterial pneumonia

Fungal infection

Hepatitis C virus (HCV)

Human immunodeficiency virus (HIV) type 1

Influenza types A and B

Macrolide-resistant respiratory infection

Methicillin-resistant Staphylococcus aureus (MRSA); Coagulase-negative MRSA

Multi-drug resistant respiratory pathogens

Multi-resistant bacterial infection

Resistant Gram-positive and Gram-negative bacteria

Sepsis

Musculoskeletal

Juvenile arthritis

Osteoporosis

Prevention of ischemia-reperfusion injury associated with solid organ transplantation

Prophylaxis of solid organ rejection in transplantation

Rheumatoid arthritis

Neurology/Central Nervous System (CNS)

Acute spinal cord injury

Alzheimer's disease

Anesthesia

Epilepsy

Fabry disease

Insomnia

Lennox-Gastaut syndrome

Migraine

Minimal-to-moderate sedation for brief diagnostic and therapeutic procedures

Multiple sclerosis

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Pain (acute, generalized, inflammatory, moderate to severe, neuropathic, adjunctive opioid analgesics)

Parkinson’s disease; motor complications and psychosis associated with Parkinson's disease

Peritumoral brain edema

Restless leg syndrome

Oncology

Acute myeloid leukemia (relapsed or refractory; Fms-Related Tyrosine Kinase 3 [FLT3] mutation)

Advanced hepatocellular carcinoma

Advanced malignancies

Advanced recurrent malignant glioma

Advanced solid tumors

Chemotherapy-induced nausea and vomiting

Glioblastoma multiforme

Hematologic malignancies

Lung cancer

Lymphoma

Malignant gynecologic diseases

Melanoma

Mutation-positive tumors

Myeloproliferative neoplasms

Non-small-cell lung cancer (NSCLC)

Epidermal Growth Factor Receptor (EGFR) activating mutation-positive (EGFRm+)

Ovarian cancer

Prostate cancer (metastatic castrate-resistant; metastatic hormone-sensitive)

Refractory solid tumors

Pediatrics

Acute otitis media

Congenital cytomegalovirus

Enteroviral sepsis and meningitis

Pathogenic Escherichia coli

Viral respiratory infection

Psychiatry

Schizophrenia

Stimulant addiction

Renal

Nephropathic cystinosis

Uremic pruritus (ESRD)

Respiratory

Chronic obstructive pulmonary disease (COPD)

Nasal congestion

Reversible airflow obstruction associated with chronic asthma and other chronic lung diseases

Urology

Erectile dysfunction

Nocturia associated with nocturnal polyuria

Vaccine

Plague

Women’s Health

Bacterial vaginosis

Endometriosis

Postmenopausal symptoms

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